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Note: Participants not completing the study had medical problems precluding further participation in the study or they did not follow through with rehabilitation.
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A retrospective study by Giri et al indicated that in adolescent boys with constitutional delay of growth and puberty, height velocity is improved 1 year after treatment with intramuscular testosterone, although, as stated above, final predicted height is not affected by the therapy. Constant, persistent, uncontrolled pain will, over time, exert enough stress on the hypothalamus and pituitary (GnRH, LH, FSH) to cause the inadequate secretion of testosterone from the adrenal and gonads.
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